Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
What NMN Supplements Do?
NMN supplements are mainly used to increase NAD+ levels to improve metabolic diseases and slow down the aging process.
Improve metabolic diseases: Studies have shown that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity.
Delay the aging process: NMN can increase the vitality of cells, improve the metabolic process of cells, and delay the aging process.
Protect DNA: NAD+ is an important metabolic substance in cells and participates in various biological processes such as cellular energy metabolism and DNA repair. Supplementing NMN can increase NAD+ levels and protect DNA.
Improves Athletic Capacity: NMN has been shown to improve athletic performance and increase fat burning ability
Improve neurodegenerative diseases: Studies have shown that NMN can improve neurodegenerative diseases, such as Alzheimer's disease
However, these studies were small, and NMN has not been shown to be effective in clinical trials, so further research is needed to determine the effectiveness of NMN supplements.
What diseases can NMN supplements treat?
NMN (Nicotinamide Mononucleotide) is a substance similar to vitamin B3, which can produce NAD+ (a key metabolic intermediate) in the body. Therefore, studies have shown that NMN may help improve aging-related health issues such as metabolism, immunity, cell repair, brain health, and more.
Currently, NMN supplements are mainly used to treat the following diseases:
Aging-related metabolic disorders such as diabetes, obesity, high cholesterol, etc.
Aging-related neurodegenerative diseases, such as Alzheimer's disease.
Aging-associated immune decline.
Aging-related cardiovascular disease.
What are the purposes of NMN supplements?
NMN supplements are mainly used to increase NAD+ levels to improve metabolic diseases and slow down the aging process.
Improve metabolic diseases: Studies have shown that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity.
Delay the aging process: NMN can increase the vitality of cells, improve the metabolic process of cells, and delay the aging process.
Protect DNA: NAD+ is an important metabolic substance in cells and participates in various biological processes such as cellular energy metabolism and DNA repair. Supplementing NMN can increase NAD+ levels and protect DNA.
Improves Athletic Capacity: NMN has been shown to improve athletic performance and increase fat burning ability
Improve neurodegenerative diseases: Studies have shown that NMN can improve neurodegenerative diseases, such as Alzheimer's disease
User Reviews
What users say about BONTAC
Frequently Asked Question
Do you have any question?
NMN supplements may cause side effects such as upset stomach, diarrhea, and nausea. There is also research showing that NMN supplements may affect insulin sensitivity and insulin levels, so people with diabetes should consult their doctor before taking them.
NMN supplements have not yet undergone large-scale clinical trials to verify their effectiveness. Currently, research on NMN supplements is mainly focused on animal and in vitro experiments. These studies show that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity, and can delay the aging process.
The long-term health effects of NMN supplementation are not well studied. Existing studies mainly focus on animal and in vitro experiments, which show that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity, and can delay the aging process. However, the results of these studies do not represent the long-term effects of NMN on human health.
Our updates and blog posts
Tight Connection of NADP+/NADPH Balance with Cardiovascular Pathologies
Introduction Cardiovascular diseases (CVD) poses huge economic burden and great threat to the life of patients, even surpassing Alzheimer's disease and diabetes. 17.9 million people in the world die from CVD, with indirect treatment costs of $237 billion per year, which are projected to increase to $368 billion by 2035. It has been reported that the deficiency or imbalance of oxidized nicotinamide adenine dinucleotide phosphate (NADP+)/reduced nicotinamide adenine dinucleotide phosphate (NADPH) redox couple has been linked to a variety of pathological conditions including CVD. NADP(H) redox couple as cofactor/electron carrier in cardiommyocytes NADPH is an essential cofactor of glutathione reductase (GR) and thioredoxin reductase (TRs) in cardiommyocytes, with a crucial role in maintaining cellular redox homeostasis and energy metabolism. GR catalyzes the recycling of Glutathion (GSH) from oxidized glutathione (GSSG), and TRs reduces oxidized Trx-S2 into Trx-(SH)2. Simultaneously, both enzymes require NADPH as an electron donor and oxidize it to NADP+. Once O2•− is formed, for example, from NOXs in the cytosol and from mitochondrial electron transport chain (ETC), cytosolic CuZnSOD and mitochondrial MnSOD will reduce it to H2O2. GSH can be used by glutathione peroxidase (GPx) to reduce H2O2 further to water. Trx-(SH)2 provides reducing equivalents for Prx in the removal of H2O2. The connection of NADP(H) with cardiovascular pathologies NADP(H) plays a dual role in cardiovascular pathologies. On the one hand, the reduced NADPH can result in significant antioxidant deficiencies and intracellular accumulation of free radicals, which triggers lipid peroxidation, inflammation, and vascular dysfunction, ultimately exacerbating the course of atherosclerosisoxidase. On the other hand, high NADPH level can give rise to myocardial injury by inducing reductive stress and enhancing reactive oxygen species (ROS) production. Conclusion Changes in cellular NADP(H) content affect the intermediary metabolism of cardiac function, especially in diseased myocardium. Maintaining the balance between NADP+ and NADPH in cardiommyocytes is critically important for the treatment of CVD. Either deficiency or excess NADP(H) levels can lead to imbalances in cellular redox state and metabolic homeostasis, resulting in energy stress, redox stress, and ultimately disease state. NADP(H) has an important therapeutic value in CVD. Reference Sun Y, Wu D, Hu Q. NADP+/NADPH in Metabolism and its Relation to Cardiovascular Pathologies. Curr Med Chem. Published online February 16, 2024. doi:10.2174/0109298673275187231121054541 BONTAC NADP(H) BONTAC has dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team consisting of Doctors and Masters. BONTAC has rich R&D experience and advanced technology in the biosynthesis of NADP(H). Bonzyme whole-enzymatic method is adopted, which is environmental-friendly, with no harmful solvent residues. The purity of NADP and NADPH can reach up to 95% and 98%, respectively, which is benefited from the exclusive Bonpure seven-step purification technology. BONTAC has self-owned factories and has obtained a number of international certifications, where high quality and stable supply of products can be ensured. BONTAC has four domestic and foreign NADPH patents, leading the industry. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
Revolutionizing Biotechnical Research: BONTAC's Trailblazing Discoveries
Revolutionizing Biotechnical Research: BONTAC's Trailblazing Discoveries In the dynamic realm of biotechnical research, BONTAC stands at the forefront of innovation, dedicated to driving progress and breakthroughs in the field. Our commitment to excellence is demonstrated through our pioneering research initiatives, cutting-edge products, and unwavering focus on technical innovation. At BONTAC, we continuously strive to push the boundaries of biotechnical products to revolutionize industries and improve life. Advancing Biotechnical Research at BONTAC Within BONTAC's research laboratories, a culture of exploration and discovery fuels our quest for innovative solutions in biotechnical research. Our team of experts combines scientific expertise with creative insights to tackle complex challenges and uncover new opportunities. BONTAC's investment in state-of-the-art technology and research facilities underscores our dedication to advancing biotechnical research for the betterment of society. Impactful Applications of Biotechnical Research The fruits of BONTAC's biotechnical research are evident in our array of products that harness the power of scientific insights and technological advancements. These products are the result of meticulous research and development processes aimed at enhancing various sectors such as healthcare, agriculture, and environmental sustainability. From novel treatment options to sustainable agricultural solutions, BONTAC's biotechnical innovations are reshaping industries and driving positive change. Collaboration and Partnerships in Biotechnical Research Collaboration lies at the heart of BONTAC's approach to biotechnical research, as we recognize the value of partnering with industry leaders and experts to accelerate innovation. By fostering strategic alliances and engaging with key stakeholders, BONTAC creates a network of excellence that fosters collaboration, knowledge exchange, and collective progress in biotechnical research. Altogether, we aim to shape the future of biotechnical innovation and deliver impactful solutions to global challenges. Our commitment to advancing cellular rejuvenation extends beyond product development. We actively collaborate with leading researchers, medical professionals, and scientific institutions to stay at the forefront of this rapidly evolving field. By fostering partnerships and engaging in knowledge-sharing, we ensure that our customers benefit from the latest scientific advancements and breakthroughs in cellular rejuvenation. Conclusion In conclusion, BONTAC's dedication to pioneering discoveries in biotechnical research sets us apart as a leader in the field. Our focus on excellent products, robust technical support, and a commitment to technical innovation propels us toward groundbreaking advances that benefit society as a whole. Join us on this exciting journey as we continue to explore new frontiers in biotechnical research, where innovation meets excellence. Choosing BONTAC means embracing a journey toward revitalized cellular health. Our dedication to understanding the intricacies of cellular rejuvenation, combined with our commitment to innovation and collaboration, allows us to offer transformative solutions that empower individuals to live their life to the fullest. Altogether, let us embark on this path of cellular rejuvenation, unlocking the potential for optimal health and well-being.
Ginsenoside Rg3: A Promising Therapeutic Agent for Traumatic Brain Injury
Introduction According to the 2017 Commission on Traumatic Brain Injury (TBI), TBI remains one of the top three causes of injury-related death and disability up to 2030. There are 50~60 million people suffering from TBI each year, with annual expenditure of about US$ 400 billion across the world. Among all common neurological disorders, TBI has the highest incidence and poses a substantial public health burden. Strikingly, ginsenoside Rg3, a critical active pharmaceutical component extracted from the traditional Chinese medicine ginseng, has been attested to be effective in reducing neuroinflammation and damage in hippocampal neurons of mice following TBI, showing great therapeutic potential in TBI. About TBI TBI primarily results from mechanical and sports-related injuries, leading to acute degenerative changes in the central nervous system. TBI patients are often accompanied with cognitive and motor deficits. Cognitive deficits arise from hippocampal neuron damage post-TBI, while motor deficits manifest as paresis, altered muscle tone, ataxia, and impaired coordination and balance after TBI. The efficacy and safety of ginsenoside Rg3 in TBI mice Ginsenoside Rg3 effectively enhances neurological and motor functions, reduces brain water content, and alleviates hippocampal neuronal neuroinflammation and damage in TBI mice. At doses of 1, 5, 10, and 20 µM, ginsenoside Rg3 is non-toxic to microglia. Notably, ginsenoside Rg3 at 20 µM shows the most prominent efficacy in TBI mice. The underlying mechanism of ginsenoside Rg3 in alleviating TBI The role of ginsenoside Rg3 in alleviating TBI may be realized by enhancing SIRT1 expression and inhibiting the NF-kB pathway. Specifically, ginsenoside Rg3 represses the key markers associated with the NF-kB pathway, as manifested by the reduced levels of p-IKBa, INOS, and nuclear P65 proteins in the hippocampus of TBI-afflicted mice. Apart from these, treatment with NAM, a SIRT1 inhibitor, counteracts the beneficial effects of ginsenoside Rg3 on neurological and motor function recovery, as well as its mitigating effects on hippocampal neuronal damage and inflammation in TBI-afflicted mice, hinting the involvement of SIRT1 in the alleviation of TBI with ginsenoside Rg3. Conclusion Collectively, ginsenoside Rg3 (20 µM) markedly ameliorates neurological and motor functions while attenuating neuroinflammation and hippocampal neuronal damage by regulating the SIRT1/NF-kB pathway in TBI mice. Reference [1] Liu X, Gu J, Wang C, et al. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell Cycle. Published online May 25, 2024. doi:10.1080/15384101.2024.2355008 [2] Maas AIR, Menon DK, Manley GT, et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 2022;21(11):1004-1060. doi:10.1016/S1474-4422(22)00309-X BONTAC Ginsenosides BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of rare ginsenosides Rh2/Rg3, with pure raw materials, higher conversion rate and higher content (up to 99%). One-stop service for customized product solution is available in BONTAC. With unique Bonzyme enzymatic synthesis technology, both S-type and R-type isomers can be accurately synthesized here, with stronger activity and precise targeting action. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be responsible for any claims, damages, losses, expenses, or costs arising directly or indirectly from your reliance on the information and material on this website.